Chosen Solution
My iPad was run over by a car 2 months ago but ended up slightly dented and needed a new LCD screen. I just replaced the LCD screen and kept the original digitizer and it was working just fine for about a day. It randomly just stopped being responsive to touch. The home button stopped working as well, so I replaced the digitizer with a new one (purchased from RepairPartsUSA) only for the touch to still be unresponsive but home button works. I then went back replaced the new digitizer with the original to see if it made a difference and the home button worked again just fine but still no touch response. I made sure all cables were properly connected and lined up correctly. I even did a hard reset/restore and update and still nothing. Should I try a new digitizer just incase the two I have are just faulty or should I chop it up to being another issue?
As mentioned by @tech_ni above, check that there aren’t any missing components by the connectors. Usually devices can encounter heavy damage, especially when run over by vehicles. You could try another digitizer, I recommend Mobile Sentrix, but odds are the board suffered damage which might be repairable. Check your local repair shops if they specialize in microsoldering.